Hepatic lymphocytes involved in the pathogenesis of pediatric and adult non‑alcoholic fatty liver disease
| dc.contributor | Cairoli, Victoria | |
| dc.contributor | De Matteo, Elena | |
| dc.contributor | Rios, Daniela | |
| dc.contributor | Lezama, Carol | |
| dc.contributor | Galoppo, Marcela | |
| dc.contributor | Casciato, Paola | |
| dc.contributor | Mullen, Eduardo | |
| dc.contributor | Giadans, Cecilia | |
| dc.contributor | Preciado, Maria Victoria | |
| dc.contributor | Valva, Pamela | |
| dc.creator | Bertot, Gustavo | |
| dc.date | 2021-07-02 | |
| dc.date.accessioned | 2025-07-11T23:46:23Z | |
| dc.description | Fil: Bertot, Gustavo. Instituto Universitario de Ciencias de la Salud. Fundación Barceló; Argentina. | |
| dc.description | The immune response is critical in NAFLD pathogenesis, but the liver infiltrate’s composition and the role of each T cell population is still up for debate. To characterize liver pathogenesis in pediatric and adult cases, frequency and localization of immune cell populations [Cytotoxic T Lymphocytes (CD8+), T helper Lymphocytes (CD4+), Regulatory T lymphocytes (Foxp3+) and Th17 (IL-17A+)] were evaluated. In portal/periportal (P/P) tracts, both age groups displayed a similar proportion of CD8+ and CD4+ lymphocytes. However, comparable Foxp3+ and IL-17A+ cell frequencies were observed in pediatric cases, meanwhile, in adults Foxp3+ was higher than IL-17A+ cells. Interestingly, IL-17A+ lymphocytes seemed to be nearly exclusive of P/P area in both age groups. In intralobular areas, both pediatric and adult cases showed CD8+ lymphocytes predominance with lower frequencies of CD4+ lymphocytes followed by Foxp3+ . Severe inflammation was associated with higher intralobular Foxp3+ lymphocytes (p = 0.026) in children, and lower P/P Foxp3+ and higher IL-17A+ lymphocytes in adults. All cases with fibrosis ≥ 2 displayed P/P low Foxp3+ and high IL-17A+ lymphocyte counts. Pediatric cases with worse steatosis showed high P/P CD4+ (p = 0.023) and intralobular CD8+ (p = 0.027) and CD4+ cells (p = 0.012). In NAFLD cases, the lymphocyte liver infiltrate composition differs between histological areas. Treg and Th17 balance seems to condition damage progression, denoting their important role in pathogenesis. | |
| dc.format | application/pdf | |
| dc.identifier | https://repositorio.barcelo.edu.ar/greenstone/collect/investig/index/assoc/HASH37b2.dir/BRC_122_MED_BA.pdf | |
| dc.identifier | http://repositorio.barcelo.edu.ar/greenstone/collect/investig/index/assoc/HASH37b2.dir/BRC_122_MED_BA.pdf | |
| dc.identifier.uri | https://dspace.barcelo.edu.ar/handle/123456789/251 | |
| dc.language | eng | |
| dc.publisher | Nature Portfolio Scientific Reports (2021) 11:5129 | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.subject | ARTICULO | |
| dc.subject | MEDICINA | |
| dc.subject | LINFOCITOS HEPATICOS | |
| dc.subject | HIGADO GRASO | |
| dc.title | Hepatic lymphocytes involved in the pathogenesis of pediatric and adult non‑alcoholic fatty liver disease | |
| dc.type | info:eu-repo/semantics/article | |
| dc.type | info:ar-repo/semantics/artículo | |
| dc.type | info:eu-repo/semantics/publishedVersion |
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