Effect of Rosiglitazone on N-nitroso-N-methylurea-induced Mammary Tumors in Rat
| dc.creator | Bergoc, Rosa | |
| dc.date | 2020-02-27 | |
| dc.date.accessioned | 2025-07-11T23:46:20Z | |
| dc.description | Fil: Bergoc, Rosa. Instituto Universitario de Ciencias de la Salud. Fundación Barceló; Argentina. | |
| dc.description | The objective of this study was to evaluate the in vivo antitumor action of rosiglitazone (Rosi) alone or in combination with tamoxifen (Tam) on experimental mammary tumors induced by N-nitroso-N-methylurea (NMU) in Sprague-Dawley rats. Animals bearing mammary tumors were treated with 0.06 mg/kg/day or 0.12 mg/kg/day of Rosi orally, 1 mg/kg/day of Tam sc, or with the combined treatment (Rosi+Tam). After 25 days of treatments, the following responses were observed: 45% of tumors were responsive to 0.06 mg/kg/day of Rosi treatment, while 55% of tumors under Tam treatment responded. Results of the combined Rosi+Tam treatment indicate that 75% of tumors were responsive. Similar results were obtained with 0.12 mg/kg/day of Rosi. Apoptosis, necrosis and glandular hypersecretion were observed in Rosi-treated tumors. In all cases, the combined Rosi+Tam treatment potentiates the antitumor effect of Tam alone. No side-effect was observed after treatment at any assayed dose. | |
| dc.format | application/pdf | |
| dc.identifier | https://repositorio.barcelo.edu.ar/greenstone/collect/investig/index/assoc/HASHa3e2.dir/BRC_37_MED_BA.pdf | |
| dc.identifier | http://repositorio.barcelo.edu.ar/greenstone/collect/investig/index/assoc/HASHa3e2.dir/BRC_37_MED_BA.pdf | |
| dc.identifier.uri | https://dspace.barcelo.edu.ar/handle/123456789/243 | |
| dc.language | eng | |
| dc.publisher | PubMed 2006 May-Jun;26(3A):2113-22 | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.subject | ARTICULO | |
| dc.subject | MEDICINA | |
| dc.subject | CANCER DE MAMA | |
| dc.subject | FARMACOLOGIA | |
| dc.title | Effect of Rosiglitazone on N-nitroso-N-methylurea-induced Mammary Tumors in Rat | |
| dc.type | info:eu-repo/semantics/article | |
| dc.type | info:ar-repo/semantics/artículo | |
| dc.type | info:eu-repo/semantics/publishedVersion |
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